منابع مشابه
Imatinib metabolism and disposition in isolated rat perfused liver
Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملEditorial: Drug Metabolism and Disposition: the biological fate of chemicals.
Renal Catabolism of Recombinant Human Soluble CD4 after Intravenous Administration to Male Sprague-Dawley Rats. TIMOThY W. HEPBURN, CHARLES B. DAVIS, JAMES J. URBANSKI, BRIAN R. SMITh, WILLIAM H. SCHAEFER, MICHAEL A. CARBONARO, AND PETER J. BUGELSKI 1044 Metabolism of Mofarotene in Hepatocytes and Liver Microsomes from Different Species: Comparison with in Vivo Data and Evaluation of the Cytoch...
متن کاملDrug Disposition in Diseases Altering CYP450-Mediated Metabolism
Submit Manuscript | http://medcraveonline.com Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ...
متن کاملDrug Disposition in Diseases Altering CYP450-Mediated Metabolism
Submit Manuscript | http://medcraveonline.com Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ...
متن کاملClinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.
1. Absorption, distribution, metabolism, transport and elimination properties of omadacycline, an aminomethylcycline antibiotic, were investigated in vitro and in a study in healthy male subjects. 2. Omadacycline was metabolically stable in human liver microsomes and hepatocytes and did not inhibit or induce any of the nine cytochrome P450 or five transporters tested. Omadacycline was a substra...
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ژورنال
عنوان ژورنال: Veterinary Clinics of North America: Small Animal Practice
سال: 2013
ISSN: 0195-5616
DOI: 10.1016/j.cvsm.2013.05.002